Visible Light?Enhanced C?H Amination of Cyclic Ethers with Iminoiodinanes

A two-step protocol allowing the C?H amination of cyclic ethers with iminoiodinanes, followed by reduction resulting intermediate has been developed for preparation amino alcohols. The initial functionalization is accelerated visible light, improving reactivity compared to thermal process performed in dark. effect different substituents on photochemical iminoiodinanes studied both experimentally and computationally. Photophysical measurements DFT calculations were better understand observed reactivities corroborate proposed mechanistic proposal.